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Ua-26408784-1 search menu search options advanced search search help home contact us access old springerlink sign up / log in sign up / log in institutional / athens login english deutsch corporate academic look inside get access find out how to access preview-only content close neurogenetics may 2012, volume 13, issue 2, pp 133-140 jph3 repeat expansions cause a progressive akinetic-rigid syndrome with severe dementia and putaminal rim in a five-generation african-american family susanne a. women taking viagra effects Schneider, kate e. cheap generic viagra Marshall, jianfeng xiao, mark s. Ledoux … show all 4 hide look inside get access abstract we report the clinical, neuropsychological, genetic, and radiological features of a large five-generation african-american kindred from the southern usa presenting with a progressive akinetic-rigid syndrome and severe dementia, but clinically insignificant chorea, due to mutations in junctophillin 3 (jph3). women taking viagra effects Overt disease onset was in the mid-20s to late 30s with cognitive decline, rem sleep disturbance, or psychiatric features, followed by development of a levodopa-unresponsive akinetic-rigid motor syndrome. viagra shipped usa Dystonia and myoclonus were present in some subjects. buy viagra cheap A bedridden, nonverbal severely akinetic-rigid state developed within 10 to 15â years after onset. buy viagra online Ctg repeat expansions ranged from 47 to 53. viagra online Imaging revealed generalized cerebral atrophy with severe striatal involvement and putaminal rim hyperintensity. cheap viagra Analysis of our kindred indicates that jph3 mutations should be considered in the differential diagnosis of early-onset dementia and hypokinetic-rigid syndromes in individuals of african descent. Moreover, chorea may not be overtly manifest at presentation or during significant parts of the disease course. Page %p close plain text look inside within this article: introduction subjects and methods results discussion references other actions export citations register for journal updates about this journal related content supplementary material (4) blah 10048_2012_318_moesm1_esm. viagra no prescription Wmv (2854kb) esm 1: (wmv 2,853â kb) blah 10048_2012_318_moesm2_esm. Wmv (2965kb) esm 2: (wmv 2,964â kb) blah 10048_2012_318_moesm3_esm. women taking men's viagra Wmv (2842kb) esm 3: (wmv 2,842â kb) blah 10048_2012_318_moesm4_esm. Docx (2016kb) esm 4: (docx 2,015â kb) references (21) margolis rl, o'hearn e, rosenblatt a, willour v, holmes se, franz ml, callahan c, hwang hs, troncoso jc, ross ca (2001) a disorder similar to huntington's disease is associated with a novel cag repeat expansion. Ann neurol 50:373–380 margolis rl, rudnicki dd, holmes se (2005) huntington's disease like-2: review and update. Acta n. viagra and viagra comparison Date Created: Mon Jun 18 12:29:21 2007